HIV testing near the patient: changing the face of HIV testing.

Virological, epidemiologic, and operational barriers have slowed the progress toward effective management and eradication of HIV infection, despite significant advances in diagnosis since the early 1980s. Because early diagnosis profoundly affects the health care and survival of infected/high-risk individuals, and because the time required for conventional testing remains a barrier in many settings, rapid HIV testing has been developed for use both in the clinical laboratory and at the point of care. Recent studies have identified applications, advantages, and limitations of these assays, which may influence the development of new and more effective public health testing and screening protocols. In the United States, the Food and Drug Administration has approved the use of six rapid HIV tests. This review summarizes these modern rapid point-of-care HIV tests and their role in preventing the spread of HIV and in detecting, managing, and treating patients affected by the HIV pandemic.