作为血管生成调节剂的天然产物。

Natural products as angiogenesis modulators.

作者信息

El Sayed K A

机构信息

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monore, Monore, LA 71209, USA.

出版信息

Mini Rev Med Chem. 2005 Nov;5(11):971-93. doi: 10.2174/138955705774575291.

DOI:10.2174/138955705774575291

PMID:16307528

Abstract

Cancer remains one of the major causes of death worldwide. Anti-angiogenic therapy is one of the new approaches to anticancer therapy. Out of 22 angiogenesis inhibitors currently under clinical trials there are 11 natural products or were modeled on a natural product parent. This review shows the potential of natural products for the discovery of new anti-angiogenic leads.

摘要

癌症仍然是全球主要死因之一。抗血管生成疗法是抗癌治疗的新方法之一。在目前正在进行临床试验的22种血管生成抑制剂中，有11种是天然产物或基于天然产物母体构建的。这篇综述展示了天然产物在发现新的抗血管生成先导物方面的潜力。