Kotoku Naoyuki, Arai Masayoshi, Kobayashi Motomasa
Graduate School of Pharmaceutical Sciences, Osaka University.
Chem Pharm Bull (Tokyo). 2016;64(2):128-34. doi: 10.1248/cpb.c15-00744.
As angiogenesis is critical for tumor growth and metastasis, potent and selective anti-angiogenic agents with novel modes of action are highly needed for anti-cancer drug discovery. In this review, our studies focusing on the search for anti-angiogenic substances from natural sources, such as bastadins, globostellatic acid X methyl esters and cortistatins from marine sponges, and pyripyropenes from marine-derived fungus, together with senegasaponins from medicinal plant, are summarized.
由于血管生成对肿瘤生长和转移至关重要，因此在抗癌药物研发中，非常需要具有新型作用模式的强效和选择性抗血管生成药物。在本综述中，我们总结了从天然来源寻找抗血管生成物质的研究，如来自海洋海绵的bastadins、球茎酸X甲酯和皮质抑素，以及来自海洋来源真菌的吡喃并吡咯烯，还有来自药用植物的远志皂苷。
