Campos M, Cuevas K, Garbus J, Lee M, McDonnell P J
Doheny Eye Institute, Los Angeles, CA 90033.
Ophthalmology. 1992 Jun;99(6):893-7. doi: 10.1016/s0161-6420(92)31876-7.
To examine the effects of blowing nitrogen gas over the cornea during photorefractive keratectomy.
Excimer laser ablations for myopia were performed on rabbit corneas with or without the blowing of nitrogen across the surface of the cornea. All eyes underwent a 5-diopter myopic ablation; in 8 eyes, a ring was used to blow nitrogen gas across the cornea, and, in 8 eyes, the same ring was used, but no nitrogen gas was blown.
Epithelial healing occurred more rapidly in the eyes that were not treated with the gas (3.8 +/- 1.3 days) than in the gas-treated group (6.1 +/- 0.8 days; P = 0.0025). Corneal haze was greater in the group treated with gas. Results of histologic examination showed the ablated area to have a smoother surface when nitrogen was not blown across the cornea surface.
Superficial corneal deturgescence produced by the nitrogen gas appears to result in a rougher surface immediately postoperatively with undesirable effects on surface healing, but further studies will be necessary to determine the applicability of these results to humans.
研究在准分子激光原位角膜磨镶术（PRK）过程中向角膜表面吹氮气的效果。
在兔角膜上进行近视性准分子激光消融，部分角膜表面吹氮气，部分不吹。所有眼睛均进行5屈光度的近视性消融；8只眼睛使用环向角膜表面吹氮气，另外8只眼睛使用相同的环，但不吹氮气。
未接受气体处理的眼睛上皮愈合更快（3.8±1.3天），而接受气体处理的组愈合时间为（6.1±0.8天；P = 0.0025）。接受气体处理的组角膜混浊更严重。组织学检查结果显示，不向角膜表面吹氮气时，消融区域表面更光滑。
氮气产生的角膜表面浅部消肿似乎会导致术后即刻表面更粗糙，对表面愈合产生不良影响，但需要进一步研究以确定这些结果对人类的适用性。
