甲氧苄啶-磺胺甲恶唑治疗眼部弓形虫病。
Trimethoprim-sulfamethoxazole therapy for ocular toxoplasmosis.
作者信息
Opremcak E M, Scales D K, Sharpe M R
机构信息
Ohio State University, College of Medicine, Department of Ophthalmology, Columbus 43210.
出版信息
Ophthalmology. 1992 Jun;99(6):920-5. doi: 10.1016/s0161-6420(92)31873-1.
BACKGROUND
Toxoplasmosis is a leading cause of retinochoroiditis. Conventional multidrug therapy using sulfadiazine, pyrimethamine, and folinic acid is increasingly difficult to procure and administer safely.
METHODS
To evaluate the efficacy of trimethoprim-sulfamethoxazole, a fixed-combination antibiotic, patients with active toxoplasmosis were treated with trimethoprim-sulfamethoxazole (Bactrim DS) with or without adjunctive clindamycin and prednisone for 4 to 6 weeks.
RESULTS
All patients in this study (n = 16) had resolution of active retinochoroiditis and had improved vision, with an average gain of 5.2 lines of vision. Two patients developed a drug allergy.
CONCLUSION
Trimethoprim-sulfamethoxazole appears to be a safe and effective substitute for sulfadiazine, pyrimethamine, and folinic acid (Leucovorin) in treating ocular toxoplasmosis.
背景
弓形虫病是视网膜脉络膜炎的主要病因。使用磺胺嘧啶、乙胺嘧啶和亚叶酸的传统多药疗法越来越难以安全获取和给药。
方法
为评估复方新诺明（一种固定组合抗生素）的疗效，对活动性弓形虫病患者使用复方新诺明（复方磺胺甲恶唑片）治疗4至6周，部分患者加用克林霉素和泼尼松。
结果
本研究中的所有患者（n = 16）活动性视网膜脉络膜炎均消退，视力改善，平均视力提高5.2行。两名患者出现药物过敏。
结论
在治疗眼部弓形虫病方面，复方新诺明似乎是磺胺嘧啶、乙胺嘧啶和亚叶酸（甲酰四氢叶酸）的安全有效替代品。
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