Colin J, Harie J C
Service d'Ophtalmologie, CHR Brest.
J Fr Ophtalmol. 1989;12(3):161-5.
A prospective, randomized study was conducted in 29 patients with presumed toxoplasmic retinochoroiditis to compare the efficacy of oral pyrimethamine and sulfadiazine (P + S) with subconjunctival injections of clindamycin. There was no difference in the mean visual acuity in both groups after treatment; the mean healing time was similar in the two treatment groups, 1.80 months with clindamycin and 1.88 month with P + S. However subjective improvement was obtained earlier with clindamycin. After 14 months' follow up, recurrences of ocular toxoplasmosis developed in both groups, 21% with clindamycin and 36% with P + S, respectively (NS). Other than the discomfort due to topical treatment, clindamycin did not produce any side-effects, which did happened after oral P + S. Subconjunctival injections of clindamycin provide an interesting alternative in the choice of an antitoxoplasmic ocular therapy.
对29例疑似弓形虫性视网膜脉络膜炎患者进行了一项前瞻性随机研究，以比较口服乙胺嘧啶和磺胺嘧啶（P + S）与结膜下注射克林霉素的疗效。治疗后两组的平均视力无差异；两个治疗组的平均愈合时间相似，克林霉素组为1.80个月，P + S组为1.88个月。然而，克林霉素组主观改善出现得更早。随访14个月后，两组均出现眼部弓形虫病复发，克林霉素组为21%，P + S组为36%（无统计学差异）。除局部治疗引起的不适外，克林霉素未产生任何副作用，而口服P + S后则出现了副作用。结膜下注射克林霉素为抗弓形虫眼部治疗提供了一种有趣的替代选择。
