Tenenbaum Scott A, Aguirre-Ghiso Julio
Molecular Genetics, Department of Biomedical Sciences, School of Public Health, Ge*NY*Sis Center for Excellence in Cancer Genomics, 1 Discovery Drive, Room 220, Rensselaer, New York 12144, USA.
Mol Cell. 2005 Nov 23;20(4):499-501. doi: 10.1016/j.molcel.2005.11.005.
To address the role of the RS domain in shuttling and how it is differentially required for constitutive and alternative splicing, Lin et al. (2005 [in the November 11 issue of Molecular Cell]) employ an elegant somatic complementation system to reveal a novel phosphorylation-dependent mechanism regulating distinct recycling pathways for SR proteins during mRNP maturation.
为了研究RS结构域在穿梭过程中的作用,以及组成型剪接和可变剪接对其的不同需求,林等人(2005年[发表于11月11日的《分子细胞》杂志])采用了一种巧妙的体细胞互补系统,以揭示一种新的磷酸化依赖性机制,该机制在mRNA前体核糖核蛋白(mRNP)成熟过程中调节SR蛋白的不同循环途径。