Hieronymus Haley, Silver Pamela A
Department of Systems Biology, Harvard Medical School and the Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Genes Dev. 2004 Dec 1;18(23):2845-60. doi: 10.1101/gad.1256904.
Gene expression occurs through a complex mRNA-protein (mRNP) system that stretches from transcription to translation. Gene expression processes are increasingly studied from global perspectives in order to understand their pathways, properties, and behaviors as a system. Here we review these beginnings of mRNP systems biology, as they have emerged from recent large-scale investigation of mRNP components, interactions, and dynamics. Such work has begun to lay the foundation for a broader, integrated view of mRNP organization in gene expression.
基因表达通过一个从转录到翻译的复杂信使核糖核酸-蛋白质（mRNP）系统发生。为了从系统角度理解基因表达过程的途径、特性和行为，人们越来越多地从全局视角对其进行研究。在此，我们回顾mRNP系统生物学的这些开端，它们源自近期对mRNP组分、相互作用和动力学的大规模研究。此类工作已开始为基因表达中mRNP组织的更广泛、综合的观点奠定基础。
