Shanidze E, Zhvania M
Department of Specialization in Pediatrics, Tbilisi State Medical University, Georgia.
Georgian Med News. 2005 Oct(127):38-40.
Aim of study consists of establishing of some clinical-biological correlates for rheumatic fever (RF) in children, namely correlations between clinical status and lipoperoxidation products -- malonidialdehide (MDA) and antioxidative enzymes in the blood. In the neutralization process of superoxside anions ceruloplazmin (CP), catalase (CAT) and transferin (TF) are key antioxidant enzymes (AOE) of antioxidative defense system (AOD). We studied 38 patients 3-15 years of age with different variants of RF. We measured the levels of MDA, CAT, CP, TF in the plasma in patients with acute rheumatic fever (ARF) and chronic rheumatic heart disease (CRHD). In all of our cases AOE (CAT, CP, TF) were high at time of diagnosis, concomitant with increased MDA and inflammatory tests. Our study revealed intensified activity of AOD enzymes in children with RF.
本研究的目的是建立儿童风湿热（RF）的一些临床生物学相关性，即临床状况与血液中脂质过氧化产物——丙二醛（MDA）和抗氧化酶之间的相关性。在超氧阴离子的中和过程中，铜蓝蛋白（CP）、过氧化氢酶（CAT）和转铁蛋白（TF）是抗氧化防御系统（AOD）的关键抗氧化酶（AOE）。我们研究了38例3至15岁患有不同类型RF的患者。我们测量了急性风湿热（ARF）和慢性风湿性心脏病（CRHD）患者血浆中MDA、CAT、CP、TF的水平。在我们所有的病例中，诊断时AOE（CAT、CP、TF）都很高，同时MDA和炎症指标也升高。我们的研究揭示了RF患儿中AOD酶的活性增强。
