Asetskaia I L, Egorov D Iu, Kozlov A v, Nalivaĭko E S, Markin S S, Sergienko V I, Azizova O A, Vladimirov Iu A, Lopukhin Iu M
Vestn Akad Med Nauk SSSR. 1990(12):41-5.
The antioxidative system (AOS) ceruloplasmin-transferrin (Cp-Tr) was studied by means of electron paramagnetic resonance in 14 rabbits with experimental atherosclerosis and in 33 patients with ischemic heart disease (IHD). A correlation was found between the AOS Cp-Tr activity and the pathological process severity: mild disease was associated with high AOS activity, while in severe disease course, this activity was threefold lower. This regularity was detectable both in experimental animals and in human IHD patients. It was found that hemosorption (HS) exerted a positive effect only in the presence of low AOS Cp-Tr activity which increased after HS in these cases. In high AOS activity HS caused deterioration of the patients' condition and accumulation of lipid peroxidation products in the blood plasma; this was attended with lowering of the AOS Cp-Tr activity.
采用电子顺磁共振方法，对14只实验性动脉粥样硬化兔和33例缺血性心脏病（IHD）患者的抗氧化系统（AOS）铜蓝蛋白 - 转铁蛋白（Cp-Tr）进行了研究。发现AOS Cp-Tr活性与病理过程严重程度之间存在相关性：轻度疾病与高AOS活性相关，而在严重病程中，该活性降低了三倍。这种规律在实验动物和人类IHD患者中均能检测到。发现血液吸附（HS）仅在AOS Cp-Tr活性较低的情况下发挥积极作用，在这些情况下HS后活性会增加。在AOS活性高时，HS会导致患者病情恶化以及血浆中脂质过氧化产物的积累；同时伴有AOS Cp-Tr活性降低。
