腹泻与维生素A缺乏之间的相互关系：维生素A缺乏是腹泻的一个风险因素吗？

Interrelationship between diarrhea and vitamin A deficiency: is vitamin A deficiency a risk factor for diarrhea?

作者信息

el Bushra H E, Ash L R, Coulson A H, Neumann C G

机构信息

Department of Community Medicine, Faculty of Medicine, University of Khartoum, Sudan.

出版信息

Pediatr Infect Dis J. 1992 May;11(5):380-4. doi: 10.1097/00006454-199205000-00008.

DOI:10.1097/00006454-199205000-00008

PMID:1630858

Abstract

A cross-sectional study, a follow-up study and an evaluation of impact of community-based distribution of vitamin A capsules (200,000 IU) were conducted in Omdurman (Sudan) between November, 1988, and March, 1989. In the cross-sectional survey 1441 children less than 5 years of age participated, which established the baseline values for plasma retinol-binding protein. During the follow-up period 290 cases of diarrhea occurred. Low concentrations of plasma retinol-binding protein (less than 1.85 mg/dl) proved to be a risk factor for diarrhea, especially in girls. The relative risk increased after the second year of life. Children who received vitamin A supplementation before commencement of the study had a lower incidence of diarrhea. The protective effect of vitamin A supplementation was greater in girls (relative risk, 0.297; 95% confidence interval, 0.240 to 0.368) than in boys (relative risk, 0.404; 95% confidence interval, 0.352 to 0.464).

摘要

1988年11月至1989年3月期间，在苏丹恩图曼开展了一项横断面研究、一项随访研究以及一项关于社区分发维生素A胶囊（200,000国际单位）影响的评估。在横断面调查中，1441名5岁以下儿童参与其中，该调查确定了血浆视黄醇结合蛋白的基线值。在随访期间，出现了290例腹泻病例。血浆视黄醇结合蛋白浓度低（低于1.85毫克/分升）被证明是腹泻的一个危险因素，尤其是在女孩中。生命第二年之后相对风险增加。在研究开始前接受维生素A补充剂的儿童腹泻发病率较低。维生素A补充剂的保护作用在女孩中（相对风险，0.297；95%置信区间，0.240至0.368）比在男孩中（相对风险，0.404；95%置信区间，0.352至0.464）更大。