de Lima Pereira Sanívia Aparecida, Rodrigues Denise Bertulucci Rocha, da Fonseca Ferraz Mara Lúcia, da Cunha Castro Eumenia Costa, dos Reis Marlene Antonia, de Paula Antunes Teixeira Vicente
General Pathology Division, University of Uberaba, Uberaba, MG, Brazil.
Parasitol Res. 2006 Jan;98(2):153-6. doi: 10.1007/s00436-005-0023-9. Epub 2005 Nov 25.
The purpose of this study was to evaluate morphologically the tongue of individuals with chronic Chagas disease (CD) in comparison to the non-chagasic ones. Twenty-four protocol cases of autopsies were selected. They were subdivided into CD patients (10 cases) and non-chagasic ones (14 cases). The morphometric analysis was accomplished for the tongue muscle and salivary glands duct lumen area. In three CD patients, perineuritis was found, and two of them showed megaesophagus and megacolon. The intensity of the inflammation in the von Ebner's glands, the tongue muscles, and the salivary glands duct lumen area was significantly higher in the CD patients. We concluded that the CD patients show salivary glands duct dilatation, which probably would have a relation with alterations in the autonomic nervous system. The inflammation found in CD patients is in accordance with that described in comparative studies on the digestive tract and heart. These morphological findings suggest that the histopathological analysis of the tongue associated with other organs, or even in an isolated manner, can add in the diagnosis and pathogenesis of the CD chronic phase.
本研究的目的是从形态学上评估慢性恰加斯病（CD）患者的舌头，并与非恰加斯病患者进行比较。选取了24例尸检病例。他们被分为CD患者（10例）和非恰加斯病患者（14例）。对舌肌和唾液腺导管腔面积进行了形态计量分析。在3例CD患者中发现了神经炎，其中2例表现为巨食管和巨结肠。CD患者的埃伯纳腺、舌肌和唾液腺导管腔面积的炎症强度明显更高。我们得出结论，CD患者表现出唾液腺导管扩张，这可能与自主神经系统的改变有关。在CD患者中发现的炎症与在消化道和心脏的比较研究中所描述的一致。这些形态学发现表明，与其他器官相关的或甚至单独的舌头组织病理学分析，可以为CD慢性期的诊断和发病机制提供补充。
