Vazhenin A V, Fokin Al An, Tereshin O S
Vopr Onkol. 2005;51(4):485-8.
Such late-onset complications of radiotherapy as stenosis and occlusion of major arteries within fields of irradiation, designated in this paper as "post-radiation arteropathy", have not received sufficient scrutiny. The study group of 50 patients (1964-2003) included 35 females and 15 males, aged 33-77, (mean age--59 years). Total focal dose ranged 24-74.8 Gy (mean dose--48.9 Gy) per vascular bunch projection. Signs of ischemia were detected in the catchment area of irradiated artery after 8-360 months (average 90.6 months). Palliative treatment was given to 29 patients while 21 were operated on. Certain morphological features atypical of atherosclerosis were identified. Despite some negative factors, the results were not inferior to those of therapy for atherosclerosis. The hazard of stenotic effect of irradiation of major arteries in area of exposure should be perfectly clear to radiologists, oncologists and vascular surgeons.
放疗的此类迟发性并发症，如照射野内主要动脉的狭窄和闭塞，在本文中被称为“放射后动脉病”，尚未得到充分研究。研究组有50例患者（1964 - 2003年），其中女性35例，男性15例，年龄33 - 77岁（平均年龄59岁）。每个血管束投影的总局部剂量为24 - 74.8 Gy（平均剂量48.9 Gy）。照射后8 - 360个月（平均90.6个月），在受照射动脉的供血区域检测到缺血迹象。29例患者接受了姑息治疗，21例接受了手术治疗。发现了一些动脉粥样硬化不典型的形态学特征。尽管存在一些不利因素，但结果并不亚于动脉粥样硬化的治疗效果。放射科医生、肿瘤学家和血管外科医生应该清楚地认识到暴露区域主要动脉照射产生狭窄效应的风险。
