Hupp T, Kretzschmar U, Allenberg J R
Chirurg. 1987 May;58(5):328-33.
Late complications following adjuvant or curative radiotherapy become clinically more evident with increasing duration of the observation period. Atherosclerotic disease secondary to radiation therapy is a rare complication. This is a report on 10 such cases requiring reconstructive vascular surgery between 1980 and January 1986. Previous radiotherapy was performed for malignancies in 9 patients and for thyroiditis in one patient. The time interval between radiation and onset of symptoms due to radiation induced atherosclerotic disease was on average 19.5 years (5-37 years). In order to reduce wound and graft infection to a minimum the extra-anatomical position of the graft was preferred. There was no major morbidity nor mortality postoperatively. During the mean follow-up of 22 months (1-63 months) one late graft occlusion was observed. Our results show that vascular reconstruction of radiation induced atherosclerotic disease is possible. Reconstructive surgery is clearly indicated for patients who underwent previous curative therapy for malignant disease.
辅助性或根治性放疗后的晚期并发症随着观察期的延长在临床上变得更加明显。放疗继发的动脉粥样硬化疾病是一种罕见的并发症。本文报告了1980年至1986年1月期间需要进行血管重建手术的10例此类病例。9例患者先前因恶性肿瘤接受放疗，1例患者因甲状腺炎接受放疗。放疗与放疗诱发的动脉粥样硬化疾病出现症状之间的时间间隔平均为19.5年（5 - 37年）。为了将伤口和移植物感染降至最低，移植物的解剖外位置是首选。术后无重大并发症和死亡病例。在平均22个月（1 - 63个月）的随访期间，观察到1例移植物晚期闭塞。我们的结果表明，放疗诱发的动脉粥样硬化疾病的血管重建是可行的。对于先前接受过恶性疾病根治性治疗的患者，血管重建手术显然是必要的。
