来自丁迪古尔豆瓣绿的生物活性四氢呋喃木脂素。

Bioactive tetrahydrofuran lignans from Peperomia dindygulensis.

作者信息

Wu Jian-lin, Li Na, Hasegawa Toshiaki, Sakai Jun-ichi, Kakuta Saori, Tang Wanxia, Oka Seiko, Kiuchi Miwa, Ogura Hirotsugu, Kataoka Takao, Tomida Akihiro, Tsuruo Takashi, Ando Masayoshi

机构信息

Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Niigata 950-2181, Japan.

出版信息

J Nat Prod. 2005 Nov;68(11):1656-60. doi: 10.1021/np050283e.

DOI:10.1021/np050283e

PMID:16309318

Abstract

Five new tetrahydrofuran lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 microg/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments.

摘要

从细辛叶豆瓣绿的乙酸乙酯提取物中分离得到了5个新的四氢呋喃木脂素（1-5），并伴有4个已知化合物。主要通过一维核磁共振、二维核磁共振和质谱研究确定其结构。通过NOE相关确定了1-5的相对构型。其中几种化合物对三种细胞系（WI-38、VA-13和HepG2）显示出较弱的生长抑制活性。在细胞钙黄绿素积累试验中，化合物5在2.5μg/mL时表现出比维拉帕米更强的多药耐药（MDR）逆转活性。在抗炎活性实验中，化合物4和5对细胞间粘附分子-1（ICAM-1）的诱导表现出较弱的抑制活性。