Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.
Molecules. 2012 Apr 13;17(4):4474-83. doi: 10.3390/molecules17044474.
Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.
2Z-（十七-12-烯基）-4-羟基-3,4,7,8-四氢-2H-色满-5（6H）-酮（1）和 2-（十七-12-烯基）-5-羟基-5,6,7,8-四氢色满-4-酮（2），以及 11 种已知化合物：4-羟基-2-[(3,4-亚甲二氧基-苯基)十三烷酰基]环己烷-1,3-二酮（3）、油烯酮（4）、4-羟基-2-[(3,4-亚甲二氧基苯基)十一烷酰基]环己烷-1,3-二酮（5）、4-羟基-2-[(11-苯基-十一烷酰基)环己烷-1,3-二酮（6）、普罗科酮 C（7）、苏林酮 C（8）、5-羟基-7,8,4'-三甲氧基黄酮（9）、5-羟基-7,8,3',4'-四甲氧基黄酮（10）、5-羟基-7,3',4'-三甲氧基黄酮（11）、5,8-二羟基-7,3',4'-三甲氧基黄酮（12）和头孢酮 B（13），从 Peperomia dindygulensis Miq 的全植物中分离得到。它们的结构通过包括 2D-NMR 技术在内的光谱方法阐明。化合物 2、3、5 和 8 抑制人脐静脉内皮细胞（HUVEC）增殖，化合物 5 和 8 显著抑制 HUVEC 管形成。
