肠道肽与中枢黑皮质素系统在能量平衡调节中的相互作用。

Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis.

作者信息

Ellacott Kate L J, Halatchev Ilia G, Cone Roger D

机构信息

Vollum Institute and The Center for Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239-3098, USA.

出版信息

Peptides. 2006 Feb;27(2):340-9. doi: 10.1016/j.peptides.2005.02.031. Epub 2005 Nov 22.

DOI:10.1016/j.peptides.2005.02.031

PMID:16309792

Abstract

Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY(3-36).

摘要

遗传学和药理学研究表明，中枢黑皮质素系统在能量平衡调节中起关键作用。中枢黑皮质素系统存在缺陷的动物和人类表现出典型的黑皮质素肥胖表型，其特征为肥胖增加、食欲亢进、代谢缺陷和线性生长增加。除了与瘦素等能量平衡的长期调节因子相互作用外，最新数据表明，中枢黑皮质素系统也对参与介导饱腹感的肠道释放肽产生反应。在这篇综述中，我们将讨论这些系统之间的相互作用，尤其着重于胆囊收缩素（CCK）、胃饥饿素和PYY（3-36）。