Hui Xu, Desrivot Julie, Bories Christian, Loiseau Philippe M, Franck Xavier, Hocquemiller Reynald, Figadère Bruno
Laboratoire de Pharmacognosie et Groupe Chimiothérapie Antiparasitaire (associé au CNRS-BioCIS) Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.
Bioorg Med Chem Lett. 2006 Feb 15;16(4):815-20. doi: 10.1016/j.bmcl.2005.11.025. Epub 2005 Nov 23.
A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).
合成了一系列29种新型喹喔啉，并在体外对几种寄生虫（杜氏利什曼原虫、布氏布氏锥虫和阴道毛滴虫）进行了评估。其中几种表现出有趣的活性，特别是四种喹喔啉酰胺显示出体外抗利什曼原虫特性（半数抑制浓度小于20微摩尔）。
