Williams D L, Brancker W M
Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK.
Vet J. 2006 Nov;172(3):501-5. doi: 10.1016/j.tvjl.2005.08.021. Epub 2005 Nov 23.
Cystic lesions in the eyes of farmed halibut with a number of ocular sequelae have been reported previously with evidence that the condition can be associated with increased activity of choroidal carbonic anhydrase and elevated oxygen tension in the aqueous humour of affected fish. These changes may be compared to the 'bends' in human divers which are characterized by elevated circulating levels of nitrogen together with aggravating factors such as physical exercise. It is postulated that bubble formation and subsequent development of cysts in halibut require not only high aqueous humour oxygen tension but also the imposition of factors such as handling or intraspecific aggression which lead to bubble formation. A significantly higher incidence of lesions was noted in fish handled, weighed and measured every two weeks compared with a control group of unhandled fish, suggesting that physical activity associated with handled and possibly also intraspecific aggression is a factor in generation of ocular lesions in these fish.
此前已有报道称，养殖大比目鱼眼睛出现囊性病变并伴有多种眼部后遗症，有证据表明该病症可能与脉络膜碳酸酐酶活性增加以及患病鱼眼房水中氧张力升高有关。这些变化可与人类潜水员的“减压病”相比较，其特征是循环氮水平升高以及诸如体育锻炼等加重因素。据推测，大比目鱼中气泡形成及随后囊肿的发展不仅需要眼房水高氧张力，还需要诸如处理或种内攻击等导致气泡形成的因素。与未处理的对照组鱼相比，每两周进行处理、称重和测量的鱼中病变发生率显著更高，这表明与处理相关的身体活动以及可能的种内攻击是这些鱼眼部病变产生的一个因素。
