Sit K H
Department of Anatomy, Faculty of Medicine, National University of Singapore, Kent Ridge Crescent.
Singapore Med J. 1992 Jun;33(3):273-5.
The familial nature of susceptibility to rheumatic fever has been known for nearly three quarters of a century but even after massive ascertainments of affected families in 5 major cities, viz Toronto, Belfast, London, Glasgow and New York, a consensus on the exact mode of inheritance could not be reached. Reduced penetrance was suggested 40 years ago and still cited today even though the fit is poor. However with the sampling bias of the observed data resolved in the recently formulated geometric continuum v(affected-1) x P(sibship) (where O less than v----infinity) all those published ascertainments clearly show a unilocal Mendelian recessive mode of inheritance. Since rheumatic fever is clearly associated with streptococcal sore throat, I have therefore demonstrated the inheritance of an acquired trait. This Larmarckian concept is explained using simple numerical examples.
风湿热易感性的家族性特征已为人所知近四分之三个世纪，但即便在多伦多、贝尔法斯特、伦敦、格拉斯哥和纽约这五个主要城市对患病家庭进行了大规模调查之后，仍无法就确切的遗传模式达成共识。40年前有人提出了外显率降低的观点，即便拟合度不佳，如今仍被引用。然而，随着在最近提出的几何连续统v（患病数-1）×P（同胞关系）（其中0＜v＜∞）中观察数据的抽样偏差得到解决，所有已发表的调查结果都清楚地显示出单基因隐性遗传模式。由于风湿热显然与链球菌性咽喉炎有关，因此我证明了一种后天获得性状的遗传。本文用简单的数值例子解释了这一拉马克式概念。
