Gibofsky A, Khanna A, Suh E, Zabriskie J B
Bacteriology and Immunology Department, Rockefeller University, Hospital for Special Surgery, New York 10021.
J Rheumatol Suppl. 1991 Aug;30:1-5.
A large body of evidence suggests that patients with rheumatic fever immunologically respond abnormally both at a humoral and cellular level to streptococcal antigens cross-reactive with mammalian tissues. Implicit in this concept is that this abnormal immune response is genetically programmed. Using a monoclonal antibody called D8/17, a B cell marker has now been identified in 90-100% of all patients with rheumatic fever tested in 5 different geographical and ethnic populations. This trait appears to be inherited in an autosomal recessive fashion. This recognition of a B cell marker unique to individuals with rheumatic fever has important public health implications with respect to identification of individuals susceptible to rheumatic fever, possible prevention of disease and the recognition of prime candidates for future streptococcal vaccines.
大量证据表明，风湿热患者在体液和细胞水平上对与哺乳动物组织有交叉反应的链球菌抗原产生异常免疫反应。这一概念隐含的意思是，这种异常免疫反应是由基因编程的。使用一种名为D8/17的单克隆抗体，现已在5个不同地理和种族人群中接受检测的所有风湿热患者的90%-100%中鉴定出一种B细胞标志物。这种特征似乎以常染色体隐性方式遗传。对风湿热患者特有的B细胞标志物的这一认识，对于识别易患风湿热的个体、可能的疾病预防以及确定未来链球菌疫苗的主要候选对象具有重要的公共卫生意义。
