Kaiser G M, Mueller A B, Sauerwein W, Zhang H W, Westermann S, Frühauf N R, Kuehne C A, Stuschke M, Oldhafer K J, Broelsch C E
Department of General Surgery and Transplantation, University Hospital Essen, Essen, Germany.
J Invest Surg. 2005 Nov-Dec;18(6):305-13. doi: 10.1080/08941930500328748.
A large animal model was established to investigate the feasibility and suitable dosage of intraoperative radiation therapy (IORT) to the hepatic hilum before biliary-enteric anastomosis is performed. Twenty-two Pietrain Hampshire pigs underwent gallbladder and proximal bile duct resection followed by IORT using 20-40 Gy and performing biliary-enteric anastomosis. In the follow-up period of 56 days, pigs developed dose-dependent complications like stenosis of the biliary-enteric anastomosis. Results demonstrate that IORT of the liver hilum up to 20 Gy is safe with acceptable early complications in the presented animal model. The porcine biliary-enteric anastomosis can tolerate intraoperative irradiation up to a dosage of 40 Gy without disruption.
