Antoch Gerald, Kaiser Gernot M, Mueller Andrea B, Metz Klaus A, Zhang Hongwei, Kuehl Hilmar, Westermann Stephanie, Broelsch Christoph E, Mueller Stefan P, Bockisch Andreas, Debatin Jörg F
Department of Diagnostic and Interventional Radiology, University Hospital Essen, Germany.
Radiology. 2004 Mar;230(3):753-60. doi: 10.1148/radiol.2303021183. Epub 2004 Feb 5.
To assess, in a pig model, the value of dual-modality positron emission tomography (PET)/computed tomography (CT) for monitoring radiation therapy.
Central bile duct resection followed by creation of a biliodigestive anastomosis was performed in nine pigs. Six of these pigs were also treated with intraoperative radiation therapy (IORT) (20 Gy) in the area of the anastomosis. Two, 4, and 8 weeks postoperatively, contrast material-enhanced fluorine 18 fluorodeoxyglucose (FDG) PET/CT of the liver was performed in all of the animals. The radioactive tracer concentration in the region of the anastomosis was quantified, and the values were compared intraindividually with the values at the liver periphery. Histologic evaluation of the liver was performed 8 weeks postoperatively. The PET/CT images were assessed for changes in liver volume and bile duct diameter over time.
In all nine pigs, the region of the anastomosis could be clearly defined on the fused PET/CT images. PET/CT revealed a decreased concentration of FDG in the irradiated field 2 and 4 weeks after IORT. At 8 weeks, however, the distribution of the tracer in the irradiated pigs did not differ from that in the nonirradiated pigs. Homogeneous tracer uptake in all liver regions was observed in the nonirradiated animals. The CT images showed an increase in liver volume in all pigs and bile duct dilatation that increased over time in the irradiated pigs.
The morphologic and functional changes due to IORT in liver tissue can be accurately monitored with dual-modality PET/CT. By enabling the integration of functional and morphologic data, PET/CT may have an important role in monitoring radiation treatment.
在猪模型中评估双模态正电子发射断层扫描（PET）/计算机断层扫描（CT）监测放射治疗的价值。
对9头猪进行肝总管切除并建立胆肠吻合术。其中6头猪还在吻合部位接受了术中放射治疗（IORT）（20 Gy）。术后2周、4周和8周，对所有动物进行肝脏对比剂增强氟代脱氧葡萄糖（FDG）PET/CT检查。对吻合部位的放射性示踪剂浓度进行定量，并将这些值与肝脏周边区域的值进行个体内比较。术后8周对肝脏进行组织学评估。评估PET/CT图像上肝脏体积和胆管直径随时间的变化。
在所有9头猪中，吻合部位在融合的PET/CT图像上均可清晰显示。PET/CT显示IORT后2周和4周照射区域的FDG浓度降低。然而，在8周时，照射猪体内示踪剂的分布与未照射猪没有差异。未照射动物的所有肝脏区域均观察到示踪剂摄取均匀。CT图像显示所有猪的肝脏体积均增加，照射猪的胆管扩张随时间增加。
双模态PET/CT可以准确监测IORT引起的肝组织形态和功能变化。通过整合功能和形态学数据，PET/CT在监测放射治疗中可能发挥重要作用。
