Rhee Thomas K, Larson Andrew C, Prasad Pottumarthi V, Santos Elizabette, Sato Kent T, Salem Riad, Deng Jie, Paunesku Tatjana, Woloschak Gayle E, Mulcahy Mary F, Li Debiao, Omary Reed A
Department of Radiology, Northwestern University, Chicago, Illinois 60611, USA.
J Vasc Interv Radiol. 2005 Nov;16(11):1523-8. doi: 10.1097/01.RVI.0000182179.87340.D7.
Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milliseconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.
血氧水平依赖（BOLD）磁共振（MR）成像术是一种评估组织氧输送变化的非侵入性方法。研究假设，BOLD MR成像术能够检测兔VX2肝肿瘤在经聚乙烯醇颗粒肝动脉栓塞术后的氧合变化。在四个离散的VX2肝肿瘤中，表观横向弛豫时间出现了具有统计学意义的平均降低，从栓塞前的55毫秒降至栓塞后的41毫秒（P <.01）。这种降低与肝肿瘤氧合的减少相对应。使用BOLD MR成像术监测栓塞术后肝肿瘤氧合变化是可行的。这些缺氧的功能性MR成像测量结果可能作为未来研究中治疗的终点指标。
