Burgener F A
Cancer. 1980 Jul 1;46(1):56-63. doi: 10.1002/1097-0142(19800701)46:1<56::aid-cncr2820460113>3.0.co;2-c.
The effect of peripheral hepatic artery embolization was investigated in 44 rabbits with VX2 carcinomas of the liver. Embolization of the proper hepatic artery with a 175-mu polystyrene microsphere suspension (dose, 1350 or 2700 particles per rabbit) did not significantly change the survival rate as compared to controls, but did seem to delay extrahepatic tumor spread. Histologic examination suggested that partial tumor necrosis, at best, resulted from the peripheral hepatic artery embolization. It is concluded that the failure to successfully treat hepatic malignancies by means of peripheral hepatic arterial embolization and a permanent occlusive agent is due to arterial revascularization of the liver through vascular proliferation and recanalization of occluded arteries.
对44只患有VX2肝癌的兔子进行了肝外周动脉栓塞效果的研究。用175微米聚苯乙烯微球悬液（剂量为每只兔子1350或2700个颗粒）栓塞肝固有动脉，与对照组相比，并未显著改变生存率，但似乎确实延迟了肝外肿瘤的扩散。组织学检查表明，肝外周动脉栓塞充其量只能导致部分肿瘤坏死。得出的结论是，未能通过肝外周动脉栓塞和永久性闭塞剂成功治疗肝恶性肿瘤是由于肝脏通过血管增殖和闭塞动脉再通实现了动脉血运重建。
