O'Hara Ruth, Schröder Carmen M, Bloss Cinnamon, Bailey Amber M, Alyeshmerni Aviva M, Mumenthaler Martin S, Friedman Leah F, Yesavage Jerome A
Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550, USA.
Am J Geriatr Psychiatry. 2005 Dec;13(12):1107-10. doi: 10.1176/appi.ajgp.13.12.1107.
The authors examined the impact of hormone replacement therapy (HRT) on longitudinal cognitive performance (controlling for mood state) in 69 community-dwelling, postmenopausal women.
The authors conducted a 5-year follow-up of cognitive performance in 37 postmenopausal HRT users and 32 non-users. The groups did not differ with respect to age, years of education, or inter-test interval.
No main effect of HRT was observed on any of the cognitive measures, and depressive symptomatology did not affect the relationship between HRT and cognition.
Overall, our findings do not suggest that HRT affects longitudinal cognitive performance in postmenopausal, community-dwelling older women.
