Sim Kang, DeWitt Iain, Ditman Tali, Zalesak Martin, Greenhouse Ian, Goff Donald, Weiss Anthony P, Heckers Stephan
Schizophrenia and Bipolar Disorders Program, McLean Hospital/Harvard Medical School, Mill Street, Belmont, MA, 02478, USA.
Schizophr Bull. 2006 Apr;32(2):332-40. doi: 10.1093/schbul/sbj030. Epub 2005 Nov 30.
Smaller medial temporal lobe volume is a frequent finding in studies of patients with schizophrenia, but the relative contributions of the hippocampus and three surrounding cortical regions (entorhinal cortex, perirhinal cortex, and parahippocampal cortex) are poorly understood. We tested the hypothesis that the volumes of medial temporal lobe regions are selectively changed in schizophrenia. We studied 19 male patients with schizophrenia and 19 age-matched male control subjects. Hippocampal and cortical volumes were estimated using a three-dimensional morphometric protocol for the analysis of high-resolution structural magnetic resonance images, and repeated measures ANOVA was used to test for region-specific differences. Patients had smaller overall medial temporal lobe volumes compared to controls. The volume difference was not specific for either region or hemisphere. The finding of smaller medial temporal lobe volumes in the absence of regional specificity has important implications for studying the functional role of the hippocampus and surrounding cortical regions in schizophrenia.
内侧颞叶体积较小是精神分裂症患者研究中常见的发现，但海马体及三个周围皮质区域（内嗅皮质、嗅周皮质和海马旁皮质）的相对作用仍知之甚少。我们检验了内侧颞叶区域体积在精神分裂症中存在选择性变化的假设。我们研究了19名男性精神分裂症患者和19名年龄匹配的男性对照受试者。使用三维形态测量方案估计海马体和皮质体积，以分析高分辨率结构磁共振图像，并使用重复测量方差分析来检验区域特异性差异。与对照组相比，患者的内侧颞叶总体积较小。体积差异并非特定于某一区域或半球。在没有区域特异性的情况下内侧颞叶体积较小这一发现，对于研究海马体及周围皮质区域在精神分裂症中的功能作用具有重要意义。
