Orr William C
Lynn Health Sciences Institute, Oklahoma University Health Sciences Center, Oklahoma City, 73112-5550, USA.
Digestion. 2005;72(4):229-38. doi: 10.1159/000089957. Epub 2005 Nov 25.
Approximately three quarters of individuals who suffer from gastroesophageal reflux disease (GERD) experience its symptoms at night. Nighttime GERD symptoms disturb sleep and diminish quality of life more so than daytime symptoms. Nighttime gastroesophageal reflux is common in individuals with respiratory disorders such as sleep apnea and asthma, and may affect the severity and the frequency of these disorders. The treatments of choice for nighttime GERD symptoms are proton pump inhibitors (PPIs) due to their efficacy in relieving day- and nighttime GERD symptoms and controlling acid secretion. The onset of action, degree of acid suppression, and duration of effect of PPIs have important implications for the use of these therapies in clinical practice. PPIs that exhibit rapid and prolonged control of acid secretion may be particularly useful for treating nighttime GERD symptoms.
患有胃食管反流病（GERD）的人约有四分之三在夜间出现症状。与白天症状相比，夜间GERD症状更易干扰睡眠并降低生活质量。夜间胃食管反流在患有呼吸紊乱（如睡眠呼吸暂停和哮喘）的个体中很常见，并且可能影响这些疾病的严重程度和发作频率。由于质子泵抑制剂（PPI）在缓解白天和夜间GERD症状以及控制胃酸分泌方面具有疗效，因此是治疗夜间GERD症状的首选药物。PPI的起效时间、抑酸程度和作用持续时间对这些疗法在临床实践中的应用具有重要意义。能够快速且持久地控制胃酸分泌的PPI可能对治疗夜间GERD症状特别有用。
