School of Medicine, Ewha Womans University, Seoul, Korea.
J Neurogastroenterol Motil. 2010 Jan;16(1):22-9. doi: 10.5056/jnm.2010.16.1.22. Epub 2010 Jan 31.
Gastroesophageal reflux disease (GERD) and sleep disturbances are both common health problems. There is a significant association between disturbed sleep and GERD, and this may be bidirectional. Sleep disorders may induce gastrointestinal (GI) disturbances, while GI symptoms also may provoke or worsen sleep derangements. Reflux of gastric acid is a less frequent event during sleep, however, acid clearance mechanisms (including swallowing, salivation and primary esophageal motility) are impaired during sleep resulting in prolongation of acid contact time. Nighttime reflux can lead to sleep disturbance and sleep disturbance may further aggravate GERD by prolonged acid contact time and heightened sensory perception. This may facilitate the occurrence of complicated GERD and decreased quality of life. However, the interplay between sleep problems and GERD is complex, and there are still relatively limited data on this issue. Further investigation of sleep-related GERD may identify common pathophysiological themes and new therapeutic targets.
胃食管反流病（GERD）和睡眠障碍都是常见的健康问题。睡眠障碍与 GERD 之间存在显著关联，而且这种关联可能是双向的。睡眠障碍可能会引起胃肠道（GI）紊乱，而 GI 症状也可能引发或加重睡眠紊乱。然而，在睡眠期间，胃酸反流的发生频率较低，但是，酸清除机制（包括吞咽、唾液分泌和原发性食管动力）在睡眠期间受到损害，导致酸接触时间延长。夜间反流会导致睡眠障碍，而睡眠障碍可能通过延长酸接触时间和增强感觉知觉进一步加重 GERD。这可能会促进复杂的 GERD 的发生和生活质量的下降。然而，睡眠问题和 GERD 之间的相互作用是复杂的，关于这个问题的数据仍然相对有限。进一步研究与睡眠相关的 GERD 可能会发现常见的病理生理主题和新的治疗靶点。
