Foelster-Holst R, Nagel F, Zoellner P, Spaeth D
Department of Dermatology, University of Kiel, Germany.
Dermatology. 2006;212(1):66-9. doi: 10.1159/000089025.
The wet-wrap treatment has been reported to be beneficial in acute episodes of atopic dermatitis (AD) skin lesions.
The efficacy of topical corticosteroid prednicarbat with and without additional wet-wrap dressing was investigated in a prospective, randomized and controlled study.
In the left-right comparison study, 24 adults and children with an acute episode of AD were included. One arm or leg was randomly treated with the topical corticosteroid prednicarbat plus wet-wrap dressing; only prednicarbat was applied on the leg or arm of the other side.
After 48-72 h of treatment, in both groups an improvement of the local SCORAD was observed. In comparison to the side of the body treated with corticosteroid alone, the decrease of the local SCORAD in the corticosteroid plus wet-wrap dressing group was significantly better. The severity of AD improved in the wet-wrap group at an average of 4.4 points, in the corticosteroid group 3.0 (p<0.011).
Wet-wrap therapy with a topical corticosteroid is an effective treatment option in patients with exacerbated AD. The treatment is helpful in improving skin conditions, shortening the time of corticosteroid application.
据报道，湿敷疗法对特应性皮炎（AD）皮肤病变的急性发作有益。
在一项前瞻性、随机对照研究中，研究了外用皮质类固醇泼尼松龙在有无额外湿敷敷料情况下的疗效。
在左右对比研究中，纳入了24名患有AD急性发作的成人和儿童。一侧手臂或腿部随机接受外用皮质类固醇泼尼松龙加湿敷敷料治疗；另一侧手臂或腿部仅涂抹泼尼松龙。
治疗48 - 72小时后，两组局部SCORAD均有改善。与仅使用皮质类固醇治疗的身体一侧相比，皮质类固醇加湿敷敷料组的局部SCORAD降低明显更好。湿敷组AD严重程度平均改善4.4分，皮质类固醇组改善3.0分（p<0.011）。
外用皮质类固醇的湿敷疗法是AD病情加重患者的有效治疗选择。该治疗有助于改善皮肤状况，缩短皮质类固醇的应用时间。
