Schnopp Christina, Holtmann Christiane, Stock Sybille, Remling Roland, Fölster-Holst Regina, Ring Johannes, Abeck Dietrich
Department of Dermatology and Allergy am Biederstein, Technical University of Munich, Germany.
Dermatology. 2002;204(1):56-9. doi: 10.1159/000051811.
The wet-wrap dressing technique has proved to be beneficial in cases of exacerbated atopic dermatitis (AD) skin lesions.
The effect of wet-wrap dressings was investigated in a controlled trial comparing a steroid (mometasone furoate 0.1%)-containing and a steroid-free (vehicle) preparation in an in-patient comparison study.
20 children aged 2-17 years with exacerbated AD were treated twice daily with wet-wrap dressings over a 5-day period.
AD in treated areas significantly improved in both study arms; however, the effect was significantly better in the mometasone-treated group (p < 0.01). Transepidermal water loss improved in both arms without any significant differences. Staphylococcus aureus colonization decreased during the first 3 days of active treatment independently of the therapeutic modalities chosen. At day 5, colony counts further dropped on the steroid-treated lesions.
Application of the wet-wrap dressing technique for exacerbated AD lesions is effective, combination with a topical steroid being superior to a steroid-free application without bearing the risk of a bacterial superinfection.
湿包裹敷料技术已被证明对特应性皮炎（AD）皮肤病变加重的病例有益。
在一项住院对照研究中，通过对照试验研究了湿包裹敷料在含类固醇（糠酸莫米松0.1%）制剂和不含类固醇（赋形剂）制剂中的效果。
20名年龄在2至17岁的AD病情加重的儿童，在5天时间内每天接受两次湿包裹敷料治疗。
两个研究组中治疗部位的AD均有显著改善；然而，在糠酸莫米松治疗组效果明显更好（p < 0.01）。两组的经表皮水分流失均有改善，无显著差异。无论选择何种治疗方式，在积极治疗的前3天，金黄色葡萄球菌定植均减少。在第5天，类固醇治疗的皮损处菌落计数进一步下降。
将湿包裹敷料技术应用于AD加重的皮损是有效的，与局部类固醇联合使用优于不含类固醇的应用，且不存在细菌二重感染的风险。
