Davila Marta L
Department of Gastrointestinal Medicine and Nutrition, University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.
Curr Opin Gastroenterol. 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b.
This review will cover the recent literature pertaining to the pathogenesis, diagnosis, and management of patients with neutropenic enterocolitis.
Neutropenic enterocolitis, also referred to as typhlitis, is a life-threatening gastrointestinal complication of chemotherapy, most often associated with leukemia or lymphoma. Recently, a larger number of reports have been published of individuals presenting with this syndrome after being treated with newer chemotherapeutic agents for solid tumors such as non-small cell lung, ovarian, and peritoneal cancer, as well as following autologous stem cell transplantation. Recent studies have also better characterized computed tomographic and ultrasonographic features of this entity that can help differentiate neutropenic enterocolitis from other gastrointestinal complications. A newly published systematic analysis of the literature, which included 145 articles, defines appropriate diagnostic criteria and treatment recommendations.
Neutropenic enterocolitis is a serious, potentially lethal complication of anticancer therapy. The studies discussed in this review will help the practitioner make an appropriate, early diagnosis and implement a therapeutic program that would improve the outcome of these patients.
本综述将涵盖近期有关中性粒细胞减少性小肠结肠炎患者发病机制、诊断和管理的文献。
中性粒细胞减少性小肠结肠炎，也称为盲肠炎，是化疗的一种危及生命的胃肠道并发症，最常与白血病或淋巴瘤相关。最近，有大量报告称，在接受非小细胞肺癌、卵巢癌和腹膜癌等实体瘤的新型化疗药物治疗后，以及自体干细胞移植后，个体出现了这种综合征。最近的研究也更好地描述了该疾病的计算机断层扫描和超声特征，这有助于将中性粒细胞减少性小肠结肠炎与其他胃肠道并发症区分开来。一项新发表的对145篇文章的文献系统分析定义了适当的诊断标准和治疗建议。
中性粒细胞减少性小肠结肠炎是抗癌治疗的一种严重的、潜在致命的并发症。本综述中讨论的研究将有助于从业者做出适当的早期诊断，并实施能改善这些患者预后的治疗方案。
