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紫杉醇诱导的肠穿孔：急性腹痛的罕见原因。

Paclitaxel-Induced Bowel Perforation: A Rare Cause of Acute Abdomen.

作者信息

Shaikh Danial Haris, Baiomi Ahmed, Mehershahi Shehriyar, Abbas Hafsa, Gongati Sudharshan, Nayudu Suresh Kumar

机构信息

Division of Gastroenterology, BronxCare Hospital Center, a Clinical Affiliate of Mount Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, New York, New York, USA.

Department of Medicine, BronxCare Hospital Center, a Clinical Affiliate of Mount Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, New York, New York, USA.

出版信息

Case Rep Gastroenterol. 2020 Dec 14;14(3):687-694. doi: 10.1159/000510131. eCollection 2020 Sep-Dec.

DOI:10.1159/000510131
PMID:33442350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7772844/
Abstract

Paclitaxel, a chemotherapeutic agent, is routinely administered for the treatment of various solid organ malignancies. In rare instances, patients receiving infusions of paclitaxel may present with signs of an acute abdomen. Ischemia and necrosis of the bowel wall from chemotherapy-induced neutropenia and direct toxic effects of the drug have been implicated as the cause. We present a case of necrotizing small and large bowel perforation in a patient with breast cancer, 2 weeks after paclitaxel administration.

摘要

紫杉醇是一种化疗药物，常用于治疗各种实体器官恶性肿瘤。在罕见情况下，接受紫杉醇输注的患者可能会出现急腹症的症状。化疗引起的中性粒细胞减少导致的肠壁缺血坏死以及药物的直接毒性作用被认为是病因。我们报告一例乳腺癌患者在使用紫杉醇两周后出现坏死性小肠和大肠穿孔的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fc7/7772844/3f47b05b6f68/crg-0014-0687-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fc7/7772844/6b4a9b664b3c/crg-0014-0687-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fc7/7772844/3f47b05b6f68/crg-0014-0687-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fc7/7772844/6b4a9b664b3c/crg-0014-0687-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fc7/7772844/3f47b05b6f68/crg-0014-0687-g02.jpg

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2
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World J Gastrointest Pathophysiol. 2019 Oct 15;10(3):36-41. doi: 10.4291/wjgp.v10.i3.36.
3
[A case of multiple intestinal perforation secondary to paclitaxel and carboplatin combined chemotherapy for lung cancer].
一名肝细胞癌患者在乐伐替尼治疗期间发生肠穿孔。
Case Rep Gastroenterol. 2022 Aug 29;16(2):502-506. doi: 10.1159/000525569. eCollection 2022 May-Aug.
4
Metastatic osteosarcoma bowel perforation secondary to chemotherapy-induced tumour necrosis.化疗诱导肿瘤坏死继发转移性骨肉瘤肠穿孔。
BMJ Case Rep. 2022 Apr 26;15(4):e247774. doi: 10.1136/bcr-2021-247774.
Zhonghua Zhong Liu Za Zhi. 2019 May 23;41(5):399-400. doi: 10.3760/cma.j.issn.0253-3766.2019.05.016.
4
Laparoscopic diverting loop ileostomy for spontaneous colon perforation in advanced ovarian cancer.腹腔镜转流袢式回肠造口术用于晚期卵巢癌自发性结肠穿孔
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