Hock Hanno, Orkin Stuart H
Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Curr Opin Hematol. 2006 Jan;13(1):1-6. doi: 10.1097/01.moh.0000190111.85284.8f.
Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent functions in neutrophil maturation and hematopoietic stem cell biology. Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoietic development.
Progress in mapping the precise timing of requirements for myeloid transcription factors during hematopoietic development reveals a more refined picture of their sequence of action. We contrast Gfi-1's role in neutrophil development with PU.1, C/EBPalpha, and C/EBPepsilon. Gfi-1 has been found to be a major regulator of adult hematopoietic stem cells. It is required for restricting the proliferation of hematopoietic stem cells and maintaining their functional integrity. We discuss its role and compare its function with that of other regulators recently implicated in the biology of hematopoietic stem cells.
Considerable progress has been made in understanding Gfi-1's context-sensitive roles at defined stages of hematopoietic differentiation.
Gfi-1最初被鉴定为淋巴细胞中的转录抑制因子，现在人们认识到它在中性粒细胞成熟和造血干细胞生物学中具有重要的独立功能。在此，我们综述了最近有关Gfi-1及其在造血发育中细胞背景特异性功能的研究。
在绘制造血发育过程中髓系转录因子需求的精确时间方面取得的进展揭示了它们作用顺序的更精细图景。我们将Gfi-1在中性粒细胞发育中的作用与PU.1、C/EBPα和C/EBPε进行了对比。已发现Gfi-1是成体造血干细胞的主要调节因子。它对于限制造血干细胞的增殖和维持其功能完整性是必需的。我们讨论了它的作用，并将其功能与最近涉及造血干细胞生物学的其他调节因子的功能进行了比较。
在理解Gfi-1在造血分化特定阶段的背景敏感作用方面已经取得了相当大的进展。
