Lysaker Paul H, Beattie Nicole L, Strasburger Amy M, Davis Louanne W
Day Hospital 116H, Roudebush VA Medical Center, 1481 W. 10th Street, Indianapolis, IN 46202, USA.
J Nerv Ment Dis. 2005 Dec;193(12):790-5. doi: 10.1097/01.nmd.0000188970.11916.76.
Cross-section research suggests reported childhood abuse in schizophrenia spectrum disorders is linked with graver symptom levels and social dysfunction. To examine this prospectively, we compared biweekly ratings of positive and emotional discomfort symptoms and weekly accounts of hours worked over 4 months of rehabilitation of 12 participants with schizophrenia or schizoaffective disorder and childhood sexual abuse history and 31 with schizophrenia or schizoaffective disorder and no childhood sexual abuse history. Repeated-measures ANOVA revealed the abuse group had consistently higher levels of both symptom components and poorer participation in vocational rehabilitation. A time by group effect was observed for hours of work, with the abuse group working increasingly fewer hours over time. Participants reporting abuse also were more likely to perform poorly on a test of executive function and to have particularly higher levels of hallucinations and anxiety over time. Clinical and theoretical implications are discussed.
横断面研究表明，在精神分裂症谱系障碍中，报告的童年期受虐经历与更严重的症状水平和社会功能障碍有关。为了对此进行前瞻性研究，我们比较了12名有童年期性虐待史的精神分裂症或分裂情感性障碍患者和31名无童年期性虐待史的精神分裂症或分裂情感性障碍患者在4个月康复期内的双周阳性和情绪不适症状评分以及每周工作时长记录。重复测量方差分析显示，受虐组的两种症状成分水平一直较高，职业康复参与度较低。在工作时长方面观察到了时间与组别的交互效应，受虐组随着时间推移工作时长越来越少。报告受虐的参与者在执行功能测试中表现也更差，且随着时间推移幻觉和焦虑水平尤其更高。文中讨论了临床和理论意义。
