Mychka V B, Chazova I E, Gornostaev V V, Sergienko V B
Ter Arkh. 2005;77(10):20-4.
To study effects of antihypertensive therapy with bisoprolol and actovegin on cerebral perfusion in patients with metabolic syndrome.
Thirty patients (18 women and 12 men) with metabolic syndrome and mild arterial hypertension took bisoprolol alone in a dose 5-10 mg/day, and fifteen patients received combined therapy (bisoprolol and actovegin) for 12 weeks. Before the study and 12 weeks later measurements were made of carbohydrate and lipid metabolism, single photon emission computed tomography investigated brain perfusion.
Improvement of brain perfusion was observed after both monotherapy with bisoprolol and its combination with actovegin.
Monotherapy with bisoprolol and bisoprolol combination with actovegin improved brain perfusion but the combination was more effective.
研究比索洛尔和活化素治疗代谢综合征患者高血压对脑灌注的影响。
30例（18例女性和12例男性）代谢综合征合并轻度动脉高血压患者单独服用比索洛尔，剂量为5-10毫克/天，15例患者接受联合治疗（比索洛尔和活化素）12周。在研究前和12周后测量碳水化合物和脂质代谢，采用单光子发射计算机断层扫描研究脑灌注。
比索洛尔单药治疗及其与活化素联合治疗后均观察到脑灌注改善。
比索洛尔单药治疗及其与活化素联合治疗均可改善脑灌注，但联合治疗更有效。
