Torre P M, Konur P K, Oliver S P
Department of Animal Science, University of Tennessee, Knoxville 37901-1071.
Vet Immunol Immunopathol. 1992 May;32(3-4):351-8. doi: 10.1016/0165-2427(92)90056-v.
Methods of augmenting bovine mononuclear cell responsiveness during physiological transitions of the udder may enhance resistance of the mammary gland to intramammary infections. Interleukin-2 is required for proliferation of T-lymphocytes and may contribute to B-lymphocyte proliferation. Recombinant bovine interleukin-2 (rBoIL-2) was evaluated as a potential immunoenhancer of bovine mammary gland mononuclear cells. Bovine mononuclear cells were isolated from five primiparous Holstein cows at 14-18 and 28-32 days of involution and at 7-13 days prior to parturition. Bovine blood and mammary gland mononuclear cells were highly responsive to rBoIL-2. Response of mammary gland mononuclear cells to rBoIL-2 was comparable with response of blood mononuclear cells. These data suggest that rBoIL-2 may be an effective immunoenhancer of bovine mononuclear cells during the non-lactating and prepartum periods.
在乳房生理转变过程中增强牛单核细胞反应性的方法，可能会提高乳腺对乳房内感染的抵抗力。白细胞介素-2是T淋巴细胞增殖所必需的，可能有助于B淋巴细胞增殖。重组牛白细胞介素-2（rBoIL-2）被评估为牛乳腺单核细胞的潜在免疫增强剂。在退化期的14 - 18天和28 - 32天以及分娩前7 - 13天，从5头初产荷斯坦奶牛中分离出牛单核细胞。牛血液和乳腺单核细胞对rBoIL-2反应强烈。乳腺单核细胞对rBoIL-2的反应与血液单核细胞的反应相当。这些数据表明，rBoIL-2在非泌乳期和产前可能是牛单核细胞的有效免疫增强剂。
