Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929.
作者信息
Shibuya Masaaki, Snider Barry B, Sakano Yuichi, Tomoda Hiroshi, Omura Satoshi, Ebizuka Yutaka
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Antibiot (Tokyo). 2005 Sep;58(9):599-601. doi: 10.1038/ja.2005.82.
PMID:16320765
Abstract
The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1 alpha-hydroxy-3alpha-(4'-oxoundec-(5' E)-enyl)-pyrrolizidine and 1beta-hydroxy-3 alpha-(4'-oxoundec-(5 'E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds.
摘要
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