Tao Yi, Jiang Wei, Cheng Yi-Yu, Zhang Yu-Feng
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
J Asian Nat Prod Res. 2012;14(9):826-30. doi: 10.1080/10286020.2012.697456. Epub 2012 Aug 8.
Chemical investigation of the water extracts from the Senecio cannabifolius Less. led us to find two new compounds (1 and 2), along with 12 known compounds (3-14). The two new compounds were determined as (E, 4R)-4-hydroxy-4,5,5-trimethyl-3-(3-oxobut-1-enyl)cyclohex-2-enone (1) and (E)-4-((1S, 3R, 4R)-1-hydroxy-4,5,5-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl)but-1-en-3-o-ne (2), respectively. The structures of other compounds were elucidated by extensive analysis of spectral data and in comparison with the literature values. Compounds 1 and 2 were evaluated for inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 macrophages, and compound 1 showed potent inhibitory activity with IC(50) value of 30.65 μM.
对麻叶千里光（Senecio cannabifolius Less.）水提取物的化学研究使我们发现了两种新化合物（1和2），以及12种已知化合物（3 - 14）。这两种新化合物分别被确定为（E，4R）-4-羟基-4,5,5-三甲基-3-（3-氧代丁-1-烯基）环己-2-烯酮（1）和（E）-4-（（1S，3R，4R）-1-羟基-4,5,5-三甲基-7-氧杂双环[4.1.0]庚-1-基）丁-1-烯-3-酮（2）。通过对光谱数据的广泛分析并与文献值比较，阐明了其他化合物的结构。对化合物1和2进行了针对脂多糖诱导的RAW 264.7巨噬细胞中NO产生的抑制活性评估，化合物1表现出强效抑制活性，IC（50）值为30.65 μM。
