Jan Muhammad, Orakzai Shaukat Ali, Tariq Shafique, Javid Muhammad, Ahmad Shafiq, Haroon Muhammad, Qamar Muhammad
Department of Pharmacology, Saidu Medical College, Swat, Pakistan.
J Ayub Med Coll Abbottabad. 2005 Jul-Sep;17(3):11-4.
Peptic ulcer is a common ailment for which over production of gastric acid is the main cause. This study was undertaken to find out the effects of Calcium channel blocker Verapamil and Cimetidine on volume and acidity of Carbacol induced gastric section, free and total acidity of carbachol induced gastric secretion and their effects were also compared.
Thirty rabbits of local breed weighing 1-1.5kg were used. The animals were kept on fasting for 48 hours after which the pylorus of each was ligated. Verapamil 10mg/kg, Cimetidine 2.5 mg/kg and Carbachol 600 microg/kg body weight were administered intrapertoneally in pylorus ligated rabbits.
It was found that Verapamil reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. when the difference of means values brought about by verapamil were compared with those of Cimetidine, all these differences were found statistically non significant, indicating that Verapamil has similar effect as that of Cimetidine on all parameters included in study.
Verapamil has significant effect on volume and acidity of carbachol induced gastric secretion.
消化性溃疡是一种常见疾病，胃酸分泌过多是其主要病因。本研究旨在探究钙通道阻滞剂维拉帕米和西咪替丁对卡巴胆碱诱导的胃切片体积和酸度、卡巴胆碱诱导的胃分泌游离酸度和总酸度的影响，并对它们的作用进行比较。
选用30只体重1 - 1.5千克的本地品种兔子。动物禁食48小时后，结扎每只兔子的幽门。对结扎幽门的兔子腹腔注射维拉帕米10毫克/千克、西咪替丁2.5毫克/千克和卡巴胆碱600微克/千克体重。
发现维拉帕米可降低胃分泌的体积、游离酸度和总酸度，与卡巴胆碱相比，差异具有高度统计学意义（P<0.001）。西咪替丁也有相同作用。当比较维拉帕米和西咪替丁引起的均值差异时，发现所有这些差异均无统计学意义，表明维拉帕米在研究的所有参数上与西咪替丁具有相似作用。
维拉帕米对卡巴胆碱诱导的胃分泌体积和酸度有显著影响。
