Jan Muhammad
Department of Pharmacology, College of Medicine, Dammam University, Dammam, Kingdom of Saudi Arabia.
J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):113-5.
Peptic ulcer is mostly produced due to the over production of gastric acid. This study was undertaken to find out the effects of extract from the leaves of medicinal plant Olea europea (which contains documented natural Calcium channel blocker) on volume and acidity of Carbachol induced gastric section. Its effects were also observed on liver and kidney function.
Thirty rabbits of local breed, weighing 1-1.5 kg were used. The animals were kept on fasting for 48 hours, after that the pylorus of each animal was ligated. Carbachol 600 microg/kg body weight and extract from the leaves of Olea europea 500 mg/kg body weight were administered intraperitoneally to group A and B respectively. The extract was also administered in the same dose to group C for 45 days twice daily intraperitoneally to observe its effects on liver and kidney function.
The extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (p < 0.001). When the differences of means for both the liver and kidney function were compared with that of control group, all these were found statistically non-significant indicating that the extract has no adverse effects on these organs regarding all parameters included in study.
Extract can be used effectively and safely in the treatment of hyper gastric acidity conditions and peptic ulcer after evaluation of its effects in human subjects.
消化性溃疡大多是由于胃酸分泌过多所致。本研究旨在探究药用植物油橄榄（其含有已证实的天然钙通道阻滞剂）叶提取物对卡巴胆碱诱导的胃分泌量及酸度的影响。同时也观察了其对肝脏和肾脏功能的影响。
选用30只本地品种的兔子，体重1 - 1.5千克。动物禁食48小时后，结扎每只动物的幽门。分别向A组和B组腹腔注射600微克/千克体重的卡巴胆碱和500毫克/千克体重的油橄榄叶提取物。向C组以同样剂量腹腔注射该提取物，每日两次，持续45天，以观察其对肝脏和肾脏功能的影响。
该提取物降低了胃分泌的量、游离酸度和总酸度，与卡巴胆碱相比，差异具有高度统计学意义（p < 0.001）。当将肝脏和肾脏功能的均值差异与对照组进行比较时，发现所有差异在统计学上均无显著性，这表明就研究中所包含的所有参数而言，该提取物对这些器官没有不良影响。
在评估其对人体的作用后，该提取物可有效且安全地用于治疗胃酸过多症和消化性溃疡。
