Belaia O L, Baĭder L M, Kuropteva Z V, Fomina I G
Klin Med (Mosk). 2005;83(10):57-60.
The subjects of the study were 36 patients suffering from coronary heart disease with exertional angina and postinfarction cardiosclerosis with dislipidemia. The patients were administered mexidol (2-ethyl-6-methyl-3-oxipyridin succinate), a domestically produced antioxidative agent, for 1 month in a dose of 325 mg/day together with conventional cardial therapy. The result was good and included clinical improvements and improvements in biochemical serum parameters: cholesterol level decreased by 10%, the level of low density lipoprotein cholesterol decreased by 25%, high density cholesterol level elevated by 15%. The intensity of lipid peroxidation lowered, which was manifested by decrease of the level of diene conjugates and TBA-reactive products by 27% and 42%, respectively. The patients' antioxidative status increased.
该研究的对象为36例患有劳力性心绞痛型冠心病以及心肌梗死后心硬化合并血脂异常的患者。给这些患者服用国产抗氧化剂美西多（2-乙基-6-甲基-3-氧化吡啶琥珀酸盐），剂量为每日325毫克，同时进行常规心脏治疗，持续1个月。结果良好，包括临床症状改善以及血清生化参数改善：胆固醇水平降低了10%，低密度脂蛋白胆固醇水平降低了25%，高密度胆固醇水平升高了15%。脂质过氧化强度降低，表现为二烯共轭物水平和硫代巴比妥酸反应产物水平分别降低了27%和42%。患者的抗氧化状态增强。
