手性亚磷酸酯-恶唑啉：一类用于不对称Heck反应的新型配体。

Chiral phosphite-oxazolines: a new class of ligands for asymmetric Heck reactions.

作者信息

Mata Yvette, Diéguez Montserrat, Pàmies Oscar, Claver Carmen

机构信息

Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel li Domingo, s/n, 43007 Tarragona, Spain.

出版信息

Org Lett. 2005 Dec 8;7(25):5597-9. doi: 10.1021/ol052176h.

DOI:10.1021/ol052176h

PMID:16321000

Abstract

[chemical reaction: see text]. A series of phosphite-oxazoline ligands, derived from readily available D-glucosamine, have been used for the first time in the palladium-catalyzed Heck reaction of several substrates with high regio- and enantioselectivities (ee's up to 99%) and improved activities in standard conditions.

摘要

[化学反应：见正文]。一系列由易于获得的D - 葡萄糖胺衍生而来的亚磷酸酯 - 恶唑啉配体，首次用于钯催化的几种底物的Heck反应，具有高区域选择性和对映选择性（对映体过量高达99%），并在标准条件下提高了活性。