用于高对映选择性和通用钯催化不对称烯丙基取代反应的首个手性磷酰胺-亚磷酸酯配体。
First chiral phosphoroamidite-phosphite ligands for highly enantioselective and versatile Pd-catalyzed asymmetric allylic substitution reactions.
作者信息
Raluy Eva, Claver Carmen, Pàmies Oscar, Diéguez Montserrat
机构信息
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/ Marcelli Domingo, s/n 43007 Tarragona, Spain.
出版信息
Org Lett. 2007 Jan 4;9(1):49-52. doi: 10.1021/ol0624631.
PMID:17192082
Abstract
[reaction: see text] A series of phosphite-phosphoroamidite ligands, derived from readily available d-xylose, has been successfully applied for the first time in the Pd-catalyzed allylic substitution of several substrates with different steric and electronic properties, with high enantioselectivities (ee's up to 98) and activities in standard conditions.
摘要
[反应：见正文] 一系列由易得的D-木糖衍生而来的亚磷酸酯-磷酰胺配体，首次成功应用于钯催化的几种具有不同空间和电子性质的底物的烯丙基取代反应，在标准条件下具有高对映选择性（对映体过量高达98%）和活性。
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