手性膦烯-恶唑啉配体用于钯催化的不对称烯丙基烷基化反应。
Chiral phosphaalkene-oxazoline ligands for the palladium-catalyzed asymmetric allylic alkylation.
机构信息
Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
出版信息
Org Lett. 2010 Oct 15;12(20):4667-9. doi: 10.1021/ol1020652.
PMID:20863121
Abstract
Enantioselective catalysis in moderate to excellent yields and ee's has been accomplished using a phosphaalkene-based ligand system. Specifically, the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate using a chiral P(sp(2)),N(sp(2)) ligand proceeds with a variety of malonate nucleophiles in 73-95% yield (79-92% ee).
摘要
使用基于膦烯的配体系统实现了中等至优异收率和对映选择性的催化。具体来说，使用手性 P(sp(2)),N(sp(2))配体，钯催化 1,3-二苯基-2-丙烯基乙酸酯的烯丙基烷基化反应，与各种丙二酸亲核试剂反应，产率为 73-95%（79-92%ee）。
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