Chvanov M, Petersen O H, Tepikin A
The University of Liverpool The Physiological Laboratory Crown Street, Liverpool L69 3BX, UK.
Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2273-84. doi: 10.1098/rstb.2005.1757.
Reactive oxygen and nitrogen species (ROS and RNS) play an important role in signal transduction and cell injury processes. Nitric oxide synthase (NOS)-the key enzyme producing nitric oxide (NO)-is found in neuronal structures, vascular endothelium and, possibly, in acinar and ductal epithelial cells in the pancreas. NO is known to regulate cell homeostasis, and its effects on the acinar cells are reviewed here. ROS are implicated in the early events within the acinar cells, leading to the development of acute pancreatitis. The available data on ROS/RNS involvement in the apoptotic and necrotic death of pancreatic acinar cells will be discussed.
活性氧和氮物种（ROS和RNS）在信号转导和细胞损伤过程中起重要作用。一氧化氮合酶（NOS）——产生一氧化氮（NO）的关键酶——存在于神经元结构、血管内皮中，可能还存在于胰腺的腺泡和导管上皮细胞中。已知NO可调节细胞内稳态，本文将综述其对腺泡细胞的影响。ROS与腺泡细胞内的早期事件有关，可导致急性胰腺炎的发生。本文将讨论ROS/RNS参与胰腺腺泡细胞凋亡和坏死性死亡的现有数据。
