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小脑出血作为神经源性肺水肿的病因——病例报告

Cerebellar haemorrhage as a cause of neurogenic pulmonary edema - case report.

作者信息

Gonçalves Victor, Silva-Carvalho Luís, Rocha Isabel

机构信息

Departamento de Neurocirurgia, Hospital de S. José, Lisboa, Portugal.

出版信息

Cerebellum. 2005;4(4):246-9. doi: 10.1080/14734220500325863.

Abstract

The neurogenic pulmonary edema is a rare clinical situation caused by an imbalance characterized by an excessive sympathetic outflow. It is observed mostly in young patients, is associated with brain or spinal cord haemorrhage, trauma, tumours or infections and is usually fatal. A case of neurogenic pulmonary edema in a 27-year-old woman is presented, caused by a cerebellar haemorrhage due to a vermian and paravermian arteriovenous malformation rupture. The vermian and hemispheric haemorrhage injuring the sub-lobule IX-b of the uvula induced a disruption of both carotid baroreceptor and chemoreceptor reflexes control mechanisms. Medical treatment with controlled ventilation, PEEP, diuretics and morphine reverted the pulmonary edema. After surgical treatment of the haemorrhage and cerebellar AVM the patient recovered to an almost normal social and professional life. The cerebellar lesion induced a temporary vermian sub lobule IX-b dysfunction that was responsible for the sympathetic storm that evoked the neurogenic pulmonary edema.

摘要

神经源性肺水肿是一种由交感神经输出过多导致失衡引起的罕见临床情况。多见于年轻患者,与脑或脊髓出血、创伤、肿瘤或感染有关,通常是致命的。本文介绍了一例27岁女性神经源性肺水肿病例,由蚓部和蚓旁动静脉畸形破裂导致小脑出血引起。蚓部和半球出血损伤了悬雍垂的IX - b小叶,导致颈动脉压力感受器和化学感受器反射控制机制中断。通过控制通气、呼气末正压通气、利尿剂和吗啡进行药物治疗使肺水肿得到逆转。在对出血和小脑动静脉畸形进行手术治疗后,患者恢复到几乎正常的社会和职业生活。小脑病变导致蚓部IX - b小叶暂时性功能障碍,引发了交感神经风暴,进而诱发了神经源性肺水肿。

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