Dai Qiaoding, Su Lida
Department of Rheumatism and Immunology, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou City, Zhejiang Province, PR, China.
Neuroscience Care Unit, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, PR, China.
Surg Neurol Int. 2014 Jun 30;5:103. doi: 10.4103/2152-7806.135579. eCollection 2014.
Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by an acute increase of pulmonary interstitial and alveolar fluid. It could result from a significant central nervous system (CNS) insult such as intracranial hemorrhage. However, NPE as a major presenting manifestation of cerebellar hemorrhage was seldom reported.
We introduce a rare case of a 34-year-old woman suffering from a fulminant NPE in parallel with a spontaneous cerebellar hemorrhage. Although appropriate supportive measures were taken in the neuroscience care unit, the patient failed to survive hypoxemia within 28 h after hospital admission.
Pathological lesions of the cerebellum may initiate a cascade of reactions including massive sympathetic discharge and catecholamine storm, leading to a dysfunction of both cardiovascular and respiratory systems. By far, no effective therapeutic strategies have been utilized to treat such a situation. Our present report would shed light on the underlying mechanism of NPE.
神经源性肺水肿(NPE)是一种以肺间质和肺泡液急性增加为特征的临床综合征。它可能由严重的中枢神经系统(CNS)损伤引起,如颅内出血。然而,NPE作为小脑出血的主要表现很少被报道。
我们介绍了一例罕见的34岁女性病例,该患者同时发生暴发性NPE和自发性小脑出血。尽管在神经科学监护病房采取了适当的支持措施,但患者在入院后28小时内未能从低氧血症中存活下来。
小脑的病理损伤可能引发一系列反应,包括大量交感神经放电和儿茶酚胺风暴,导致心血管和呼吸系统功能障碍。到目前为止,尚未采用有效的治疗策略来处理这种情况。我们目前的报告将有助于阐明NPE的潜在机制。