Ahn Jae Kyoun, Chung Hum, Yu Hyeong Gon
Department of Ophthalmology, Seoul National University of College Medicine, and Seoul National University Hospital, Clinical Research Institute, Seoul Artificial Eye Center, Seoul, Korea.
Ocul Immunol Inflamm. 2005 Dec;13(6):447-53. doi: 10.1080/09273940591004232.
To determine whether vitrectomy is safe and effective for the management of vitreoretinal complications in Behçet's patients with persistent panuveitis.
Patients who had undergone therapeutic vitrectomy for Behçet's panuveitis were reviewed retrospectively. Those patients who had shown persistent uveitis despite maximum medical therapy were included. Surgical outcomes were measured by an improvement in vision of 0.3 logarithm of minimum angle of resolution, acute relapse rates, and postoperative complications.
Twenty-one patients with a mean postoperative follow-up of 30 months were identified. For almost all patients visual acuity and inflammatory control were significantly improved after vitrectomy. However, patients with optic disc neovascularization (NVD) showed no improvement in their vision or inflammatory control. The postoperative rise of intraocular pressure was frequently associated with intravitreal triamcinolone acetonide injections.
Our study suggests that vitrectomy may be both safe and effective for the management of vitreoretinal complications in Behçet's patients with persistent uveitis. Patients with NVD, however, may have poor outcomes.
确定玻璃体切除术对于患有持续性全葡萄膜炎的白塞病患者的玻璃体视网膜并发症的治疗是否安全有效。
对因白塞病全葡萄膜炎接受治疗性玻璃体切除术的患者进行回顾性研究。纳入那些尽管接受了最大程度的药物治疗仍表现出持续性葡萄膜炎的患者。通过视力提高0.3最小分辨角对数、急性复发率和术后并发症来衡量手术效果。
确定了21例患者，术后平均随访30个月。几乎所有患者玻璃体切除术后视力和炎症控制均有显著改善。然而，患有视盘新生血管（NVD）的患者视力和炎症控制没有改善。眼压术后升高常与玻璃体内注射曲安奈德有关。
我们的研究表明，玻璃体切除术对于患有持续性葡萄膜炎的白塞病患者的玻璃体视网膜并发症的治疗可能既安全又有效。然而，患有NVD的患者可能预后不佳。
