白塞病活动性葡萄膜炎的荧光素血管造影与视力

Fluorescein angiography and visual acuity in active uveitis with Behçet disease.

作者信息

Yu Hyeong Gon, Kim Moon Jung, Oh Frederick Sewoong

机构信息

Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

出版信息

Ocul Immunol Inflamm. 2009 Jan-Feb;17(1):41-6. doi: 10.1080/09273940802553279.

DOI:10.1080/09273940802553279

PMID:19294573

Abstract

PURPOSE

To determine the association of fluorescein angiography characteristics with visual acuity and visual loss during medical treatment in patients with Behçet uveitis.

METHODS

Ninety-three eyes from 69 Behçet patients with active panuveitis underwent fluorescein angiography, and the characteristic findings by angiography were determined. The patients were followed with immunomodulatory treatment.

RESULTS

Diffuse vascular leakage (73.4%), diffuse macular leakage (66.0%), and disc leakage (52.7%) were the predominant angiographic findings on fluorescein angiography. Multivariate logistic regression analysis revealed that a macular window defect and disc neovascularization on fluorescein angiography were associated with poor visual acuity (<or= 20/200) (p < .05). The presence of macular ischemia on fluorescein angiography was significantly associated with the risk of visual loss (<or= 20/200) at 48 months post-treatment (p < .05).

CONCLUSIONS

These results suggest that fluorescein angiography may be helpful for predicting visual prognosis for Behçet patients with panuveitis.

摘要

目的

确定白塞氏葡萄膜炎患者接受药物治疗期间荧光素血管造影特征与视力及视力丧失之间的关联。

方法

对69例患有活动性全葡萄膜炎的白塞氏病患者的93只眼睛进行荧光素血管造影，并确定血管造影的特征性表现。对患者进行免疫调节治疗随访。

结果

荧光素血管造影的主要血管造影表现为弥漫性血管渗漏（73.4%）、弥漫性黄斑渗漏（66.0%）和视盘渗漏（52.7%）。多因素逻辑回归分析显示，荧光素血管造影上的黄斑窗缺损和视盘新生血管与视力差（≤20/200）相关（p<0.05）。荧光素血管造影上黄斑缺血的存在与治疗后48个月视力丧失（≤20/200）的风险显著相关（p<0.05）。